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Ache-relieving: Although prostaglandins and different inflammatory molecules could make pain-perceiving nerves more sensitive, cannabinoids battle back by desensitizing these nerves. Both CBD and THC target nerve receptors that help decrease the sensation of pain (TRPV1 and CB1, respectively). Moreover, not only does CBD desensitize TRPV1, however these soothing results can unfold to neighboring ache receptors.